A 26-year-old woman with secondary amenorrhea for 8 months has FSH 40 mIU/mL, LH 25 mIU/mL, and estradiol less than 20 pg/mL. The most likely diagnosis is:
- A Hypothalamic amenorrhea
- B Pituitary adenoma
- C Premature ovarian insufficiency ✓
- D Polycystic ovary syndrome
Correct answer: C. Premature ovarian insufficiency
Explanation
Elevated FSH greater than 25 to 40 mIU/mL with low estradiol confirms premature ovarian insufficiency. Hypothalamic amenorrhea shows low or normal FSH and LH. PCOS shows elevated LH with normal FSH. Pituitary adenoma may cause hyperprolactinemia but not this gonadotropin pattern.
Reference: Williams Gynecology, 4th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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