A 30-year-old woman with PCOS is being evaluated for anovulatory infertility. A mid-luteal serum progesterone level is measured to confirm ovulation. Using the standard cutoff, which progesterone value confirms ovulation?

• A ≥1.5 ng/mL
• B ≥3 ng/mL ✓
• C ≥10 ng/mL
• D ≥15 ng/mL

Explanation

A mid-luteal serum progesterone ≥3 ng/mL (≥9.5 nmol/L) is the standard threshold confirming ovulation. Values ≥10 ng/mL suggest adequate luteal function. Option A (1.5 ng/mL) is below the ovulation threshold. Option C indicates adequate luteal phase but is not the minimum to confirm ovulation. Option D is unnecessarily high as a confirmatory cutoff.

Reference: Te Linde's Operative Gynecology, 12th ed.

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