A 27-year-old woman with PCOS and anovulatory infertility is started on clomiphene citrate. Which adverse effect is specifically associated with clomiphene therapy?
- A Ovarian hyperstimulation syndrome
- B Venous thromboembolism
- C Visual disturbances ✓
- D Hepatotoxicity
Correct answer: C. Visual disturbances
Explanation
Visual disturbances (blurring, scotomas, or photophobia) are a characteristic adverse effect of clomiphene citrate, caused by its estrogen antagonist effect on the retina. They are usually reversible on discontinuation. OHSS is rare with clomiphene alone (more common with gonadotropins). VTE and hepatotoxicity are not associated with clomiphene.
Reference: Katzung's Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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