The landmark PCOS ovulation induction trial (Legro et al., NEJM 2014) compared clomiphene with letrozole in anovulatory PCOS women. The primary outcome was live birth rate. Which finding was reported?

• A Letrozole produced significantly higher live birth rates than clomiphene ✓
• B Clomiphene produced significantly higher live birth rates than letrozole
• C Combined clomiphene plus letrozole was superior to either alone
• D All regimens had equivalent live birth rates

Explanation

Legro et al. (NEJM 2014) demonstrated that letrozole produced a significantly higher live birth rate (27.5% vs 19.1%) compared with clomiphene in anovulatory PCOS patients. Multiple gestation rates were also lower with letrozole. This landmark trial shifted practice toward letrozole as first-line therapy.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.