The EMBRACE study assessed genetic testing in BRCA mutation carriers. For a woman with a BRCA1 germline mutation who has completed childbearing, current guidelines recommend risk-reducing salpingo-oophorectomy at what age?

• A Age 35–40 years ✓
• B Age 40–45 years
• C Age 45–50 years
• D At natural menopause (around age 51)

Explanation

For women with BRCA1 mutations, risk-reducing bilateral salpingo-oophorectomy (RRBSO) is recommended between ages 35–40 years after completion of childbearing, given the median age of BRCA1-associated ovarian cancer onset being around 45. For BRCA2 mutation carriers, RRBSO is recommended at 40–45 years as their ovarian cancer risk peaks later. Early RRBSO reduces ovarian cancer risk by 80–90% and reduces breast cancer risk if done premenopausally.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

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Written and medically reviewed by the StethoPrep medical team.