According to Quintero staging of TTTS, Stage III is defined by:
- A Polyhydramnios in recipient and oligohydramnios in donor, with normal Doppler
- B Hydrops fetalis in either twin
- C Death of one or both twins
- D Critically abnormal Doppler velocimetry: absent or reversed end-diastolic flow in umbilical artery, reversed flow in ductus venosus, or pulsatile flow in umbilical vein ✓
Explanation
Quintero staging of TTTS: Stage I = polyhydramnios (recipient, DVP ≥8 cm) and oligohydramnios (donor, DVP ≤2 cm), bladder visible in donor; Stage II = donor bladder not visible ('stuck twin'); Stage III = critically abnormal Doppler in either twin (absent/reversed UAEDF, reversed DV 'a' wave, pulsatile umbilical vein); Stage IV = hydrops in either twin; Stage V = demise of one or both twins. Stage III represents cardiovascular decompensation and is the threshold for intervention in most centres.
Reference: Williams Obstetrics, 26th ed.
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