A 58-year-old woman undergoes exploratory laparotomy for a large solid-cystic ovarian mass with peritoneal deposits. Histopathology shows a tumour with psammoma bodies, marked nuclear atypia, and papillary architecture lining cystic spaces. Which of the following is the most likely histological type?

• A Serous cystadenocarcinoma ✓
• B Endometrioid adenocarcinoma
• C Mucinous cystadenocarcinoma
• D Clear cell carcinoma

Explanation

Serous cystadenocarcinoma is the most common malignant epithelial ovarian tumour and classically shows papillary architecture with psammoma bodies. Mucinous tumours show goblet cells and mucin-filled spaces without psammoma bodies, while clear cell carcinoma is associated with endometriosis and shows hobnail cells with clear cytoplasm. Endometrioid carcinoma resembles endometrial adenocarcinoma and lacks psammomatous calcification as a hallmark.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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