A 28-year-old woman with stage III endometriosis is started on danazol 400 mg daily. She must be counselled about which group of adverse effects?
- A Weight gain, acne, hirsutism, and voice deepening ✓
- B Gynecomastia and galactorrhea
- C Hypercalcemia and nephrolithiasis
- D Severe hypoglycemia and weight loss
Correct answer: A. Weight gain, acne, hirsutism, and voice deepening
Explanation
Danazol is a derivative of ethisterone with weak androgenic activity that creates a hypoestrogenic, hyperandrogenic environment. Adverse effects include weight gain, fluid retention, acne, seborrhoea, hirsutism, voice deepening, and decreased breast size; some changes such as voice deepening are irreversible. It also causes hypoestrogenic effects like hot flushes and vaginal dryness. Gynecomastia and galactorrhea reflect estrogen excess, which contradicts danazol pharmacology.
Reference: Shaw's Textbook of Gynaecology, 18th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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