A 52-year-old woman with a history of uterine fibroids undergoes hysterectomy. Histopathology reveals benign smooth muscle tumor extending into the uterine veins and reaching the inferior vena cava. This condition is best described as which of the following?

• A Leiomyosarcoma with vascular invasion
• B Intravenous leiomyomatosis ✓
• C Benign metastasizing leiomyoma
• D Disseminated peritoneal leiomyomatosis

Explanation

Intravenous leiomyomatosis is a rare condition where benign smooth muscle tumor grows into venous channels, sometimes extending to the heart. Histologically it is benign and hormone-sensitive. Leiomyosarcoma shows cytologic atypia and necrosis. Benign metastasizing leiomyoma involves distant sites like lungs. Disseminated peritoneal leiomyomatosis involves peritoneal surfaces.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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