Danazol is used in the medical management of endometriosis. Its therapeutic effect is mediated by creating which hormonal milieu?

• A Hyperestrogenic, hypoandrogenic state
• B Hypothyroid, hyperprolactinemic state
• C Hyperprogestogenic, hypoestrogenic state
• D Hyperandrogenic, hypoestrogenic state ✓

Explanation

Danazol is a synthetic androgen derivative that inhibits the mid-cycle LH and FSH surge, creating a hyperandrogenic and hypoestrogenic environment. This causes atrophy of ectopic endometrial tissue. Its androgenic side effects (acne, hirsutism, voice deepening) limit long-term use. It is now largely replaced by GnRH analogues and dienogest.

Reference: Katzung Basic and Clinical Pharmacology, 15th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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