A 35-year-old woman with a known 6 cm endometrioma undergoes risk-reducing salpingo-oophorectomy for BRCA1 mutation. Histopathology incidentally reveals a 1.5 cm focus of malignancy arising within the endometrioma. Which histological subtype of ovarian carcinoma is most strongly associated with endometriosis?
- A High-grade serous carcinoma
- B Mucinous carcinoma
- C Clear cell carcinoma ✓
- D Brenner tumor
Correct answer: C. Clear cell carcinoma
Explanation
Endometriosis is most strongly associated with clear cell carcinoma and endometrioid carcinoma of the ovary. These subtypes arise from malignant transformation of endometriotic epithelium, particularly within ovarian endometriomas. High-grade serous carcinoma arises from tubal fimbriae. Mucinous tumors and Brenner tumors have no established link with endometriosis.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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