A 47-year-old woman undergoes hysterectomy for endometrial intraepithelial neoplasia diagnosed on office biopsy. What proportion of such hysterectomy specimens harbour concurrent endometrial carcinoma?
- A Less than 5 percent
- B About 15 percent
- C Up to 30 to 40 percent ✓
- D More than 70 percent
Correct answer: C. Up to 30 to 40 percent
Explanation
When hysterectomy is performed promptly after a diagnosis of endometrial intraepithelial neoplasia or atypical hyperplasia, concurrent carcinoma is found in roughly 30 to 40 percent of specimens, because sampling error means the biopsy frequently misses adjacent frank carcinoma. This underlines why the lesion must be treated as premalignant and why surveillance biopsies during progestin therapy must be thorough. Rates below 15 percent apply to simple hyperplasia without atypia.
Reference: Williams Gynecology, 4th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.