Which set of features correctly characterises Type II endometrial carcinoma?

• A Estrogen dependent, arises in atypical hyperplasia, good prognosis
• B Low grade, ER and PR positive, excellent response to progestins
• C Endometrioid histology, PTEN mutations, associated with obesity
• D Serous or clear cell histology, p53 mutations common, occurs in older women with atrophic endometrium ✓

Explanation

Type II tumours comprise uterine serous carcinoma and clear cell carcinoma. They arise in an atrophic endometrium of elderly women, are unrelated to unopposed estrogen, show frequent TP53 mutations, and carry a poor prognosis even at early stage. Options A, C and B all describe Type I endometrioid tumours, which arise through the atypical hyperplasia pathway, are estrogen driven, and have a favourable outlook.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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