Diagnostic curettage in a 54-year-old woman reports atypical endometrial hyperplasia (endometrial intraepithelial neoplasia). She undergoes hysterectomy. What proportion of such hysterectomy specimens harbours unexpected concurrent endometrial carcinoma?

• A About 40 percent ✓
• B About 15 percent
• C About 5 percent
• D About 80 percent

Explanation

Studies of hysterectomy performed after a curettage diagnosis of atypical hyperplasia or EIN find concurrent endometrial carcinoma in roughly 30 to 45 percent of specimens, reflecting either undersampling of an existing cancer or rapid field progression. This figure underpins counselling that hysterectomy is definitive management once fertility is no longer desired, and that progestin therapy demands close surveillance. The 15 percent figure corresponds loosely to progression risk estimates over time, not concurrent disease.

Reference: Berek and Novak's Gynecology, 16th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.