Which statement correctly describes the grading of clear cell carcinoma of the endometrium?

• A It is graded by mitotic count alone
• B It is graded using the same three-tier FIGO system as endometrioid carcinoma
• C Grading depends on the proportion of hobnail cells
• D It is always classified as high grade irrespective of architectural pattern ✓

Explanation

Clear cell carcinoma is a Type II endometrial carcinoma and is considered high grade by default; the FIGO architectural grading system applies only to endometrioid tumours. Its tubulocystic, papillary or solid patterns lined by clear or hobnail cells do not modify this assignment, and it behaves aggressively even without deep myometrial invasion. Applying the endometrioid grading scheme to clear cell morphology is a recognised error and the key distractor here.

Reference: Berek and Novak's Gynecology, 16th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.