A 62-year-old woman with advanced endometrial carcinoma undergoes molecular profiling. Her tumor is classified as p53 abnormal (copy-number high) according to the ProMisE classification. What is the expected prognosis for this molecular subtype?

• A Excellent prognosis, similar to POLE ultramutated
• B Intermediate prognosis, similar to MSI-H
• C Prognosis depends solely on histological grade, not molecular subtype
• D Poor prognosis, with the highest risk of recurrence ✓

Explanation

The p53 abnormal (copy-number high) subtype carries the worst prognosis among the four molecular groups. It is frequently associated with serous or high-grade endometrioid histology, advanced stage at presentation, and a high risk of distant recurrence, regardless of histological grade.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.