A 60-year-old woman with Stage IVB endometrial carcinoma (endometrioid type) is started on systemic chemotherapy for metastatic disease. What is the standard first-line chemotherapy regimen?
- A Carboplatin and Paclitaxel ✓
- B Cisplatin and 5-Fluorouracil
- C Doxorubicin monotherapy
- D Bevacizumab monotherapy
Correct answer: A. Carboplatin and Paclitaxel
Explanation
The standard first-line systemic chemotherapy for advanced or recurrent endometrial carcinoma is a combination of carboplatin and paclitaxel. This regimen has shown efficacy and tolerability, replacing older triple-drug regimens like cisplatin, doxorubicin, and paclitaxel due to a better toxicity profile.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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