A 45-year-old woman undergoes endometrial biopsy for abnormal uterine bleeding. Histology shows complex atypical hyperplasia (endometrial intraepithelial neoplasia). What is the approximate risk of progression to endometrial carcinoma if left untreated?
- A 1-3%
- B 8-10%
- C 28-40% ✓
- D 70-80%
Correct answer: C. 28-40%
Explanation
Complex atypical hyperplasia (EIN) carries a high risk of progressing to endometrioid adenocarcinoma, estimated at 28-40%. Simple hyperplasia without atypia has a very low risk of 1-3%. This high progression risk is why hysteroma is typically recommended for postmenopausal women or those who have completed childbearing.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.