Which feature is characteristic of Type II (non-oestrogen dependent) endometrial carcinoma rather than Type I?

• A Mutation of PTEN and KRAS genes
• B Presents in perimenopausal obese women with hyperoestrogenism
• C Arises in atrophic endometrium with strong p53 accumulation ✓
• D Preceded by atypical endometrial hyperplasia

Explanation

Type II tumours, chiefly serous and clear cell carcinoma, arise in an atrophic endometrium, show diffuse p53 mutation, are usually high grade, and express oestrogen and progesterone receptors weakly or not at all. They occur in older postmenopausal women without a hyperoestrogenic state. Options B and D describe Type I biology driven by unopposed oestrogen, while option A lists the typical Type I molecular alterations such as PTEN, KRAS and microsatellite instability.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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