FIGO grading of an endometrioid endometrial adenocarcinoma is assigned primarily according to which criterion?

• A Depth of myometrial invasion
• B Percentage of glandular versus solid non-squamous growth ✓
• C Degree of lymphovascular space invasion
• D Number of mitoses per 10 high power fields

Explanation

Endometrioid carcinoma is graded architecturally: less than 5 percent solid non-squamous growth is Grade 1, 6 to 50 percent is Grade 2, and more than 50 percent is Grade 3. Marked nuclear atypia raises the grade by one level. Squamous or morular differentiation is excluded from the solid component count, which is precisely why a tumour with extensive squamous metaplasia can still be well differentiated.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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