Which histological pattern is characteristic of clear cell carcinoma of the endometrium?

• A Back-to-back glands lined by stratified columnar epithelium with squamous morules
• B Glands with intracytoplasmic mucin resembling endocervical epithelium
• C Biphasic pattern with malignant glands admixed with malignant spindle cell stroma
• D Tubulocystic and papillary architecture with hobnail cells having nuclei that protrude into lumina ✓

Explanation

Clear cell carcinoma shows tubulocystic, papillary, or solid patterns with sheets of clear cells and characteristic hobnail cells whose bulbous nuclei project into glandular or cystic lumina. It belongs to type II carcinoma, carries TP53 and PTEN/PIK3CA alterations, and has a prognosis comparable to uterine serous carcinoma irrespective of stage. Option A describes grade 1 endometrioid carcinoma with squamous differentiation, and option B describes gastric-type or mucinous differentiation.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.