A 44-year-old woman with atypical endometrial hyperplasia (EIN) managed medically undergoes hysterectomy for failed progestin response. What approximate proportion of such hysterectomy specimens harbour concurrent occult endometrial carcinoma?
- A Under 5 percent
- B Up to 30 to 40 percent ✓
- C Around 15 percent
- D More than 70 percent
Correct answer: B. Up to 30 to 40 percent
Explanation
When hysterectomy follows a diagnosis of atypical endometrial hyperplasia or EIN, concurrent carcinoma is found in roughly 30 to 40 percent of specimens, frequently grade 1 endometrioid disease with minor myometrial invasion. This figure justifies complete surgical staging considerations and counselling before conservative management. Non-atypical hyperplasia carries a far lower risk of only 1 to 3 percent, which makes option C the tempting but incorrect distractor.
Reference: Berek and Hacker's Gynecologic Oncology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.