Which pair correctly matches a Type II endometrial carcinoma with its characteristic precursor lesion?

• A Uterine serous carcinoma and endometrial intraepithelial carcinoma ✓
• B Endometrioid carcinoma and endometrial intraepithelial neoplasia
• C Clear cell carcinoma and complex hyperplasia without atypia
• D Endometrioid carcinoma and serous endometrial intraepithelial carcinoma

Explanation

Serous endometrial intraepithelial carcinoma, a surface epithelial replacement by markedly atypical cells with aberrant p53 accumulation, is the recognised precursor of invasive uterine serous carcinoma. It often coexists with invasive disease elsewhere in the uterus, which explains multifocal peritoneal recurrence after hysterectomy. Endometrial intraepithelial neoplasia precedes the oestrogen dependent endometrioid pathway, and complex hyperplasia without atypia is essentially benign, making option C incorrect.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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