Lynch syndrome (hereditary non-polyposis colorectal cancer, HNPCC) is associated with a significantly elevated lifetime risk of which gynaecological malignancy?

• A Cervical carcinoma
• B Endometrial carcinoma ✓
• C Vulval carcinoma
• D Gestational trophoblastic neoplasia

Explanation

Lynch syndrome (caused by germline mutations in DNA mismatch repair genes: MLH1, MSH2, MSH6, PMS2) confers a 40–60% lifetime risk of endometrial carcinoma — in some series, endometrial cancer is the most common initial cancer in affected women. Lynch syndrome also increases risk of ovarian carcinoma (~10%). Cervical, vulval, and GTN are not Lynch-associated. Women with Lynch syndrome should receive prophylactic hysterectomy and BSO after completing childbearing.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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