Lynch syndrome (HNPCC) is associated with lifetime risk of endometrial cancer of approximately:

• A 5–10%
• B 15–25%
• C 70–80%
• D 40–60% ✓

Explanation

Women with Lynch syndrome (caused by germline mutations in MMR genes: MLH1, MSH2, MSH6, PMS2) have a lifetime risk of endometrial cancer of 40–60%, which is higher than their lifetime colorectal cancer risk (25–70%). This makes endometrial cancer the 'sentinel cancer' of Lynch syndrome in women. Gynaecologic surveillance (annual endometrial sampling) and prophylactic hysterectomy-oophorectomy after childbearing are recommended.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.