Obstetrics & Gynaecology · Ectopic Pregnancy and Gestational Trophoblastic Disease

In which of the following patients is expectant management of an ectopic pregnancy most appropriate?

  • A Beta-hCG 850 IU/L and falling on serial testing, 2 cm unruptured adnexal mass, no cardiac activity, minimal pain
  • B Beta-hCG 3,400 IU/L and rising, 2.5 cm mass with fetal cardiac activity
  • C Beta-hCG 2,200 IU/L plateauing over three weekly values with a 4 cm adnexal mass
  • D Beta-hCG 1,800 IU/L with moderate peritoneal signs and free fluid in the pouch of Douglas
Correct answer: A. Beta-hCG 850 IU/L and falling on serial testing, 2 cm unruptured adnexal mass, no cardiac activity, minimal pain

Explanation

Expectant management is reasonable only in a completely asymptomatic or minimally symptomatic woman with an unruptured ectopic under about 3 cm, no cardiac activity, and an initially low beta-hCG, generally under 1,500 IU/L, that is already declining, since many such pregnancies resolve spontaneously. Rising or plateauing levels predict persistence, cardiac activity predicts rupture risk, and peritoneal signs mandate surgery.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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