A 26-year-old woman undergoes suction evacuation for a suspected molar pregnancy. Histopathology reveals a triploid karyotype (69,XXY) with focal trophoblastic hyperplasia and scalloped chorionic villi with inclusions. What is the diagnosis?
- A Partial hydatidiform mole ✓
- B Complete hydatidiform mole
- C Invasive mole
- D Choriocarcinoma
Correct answer: A. Partial hydatidiform mole
Explanation
Partial hydatidiform mole is characterized by a triploid karyotype (69 chromosomes, usually from two sperm fertilizing one egg), focal (not diffuse) trophoblastic hyperplasia, scalloped chorionic villi, and trophoblastic inclusions. Complete moles are diploid (46,XX or 46,XY) with diffuse hyperplasia and no fetal tissue. Invasive mole shows myometrial invasion. Choriocarcinoma has no villi and shows sheets of anaplastic trophoblast. The triploid karyotype is the key distinguishing feature.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.