A 29-year-old woman with a known complete hydatidiform mole undergoes suction evacuation. Histopathology confirms complete mole with no evidence of invasion. She is counseled about the risk of developing gestational trophoblastic neoplasia (GTN) after a complete mole. What is the approximate risk of developing GTN following a complete hydatidiform mole?
- A 2-5%
- B 15-20% ✓
- C 30-40%
- D 50-60%
Correct answer: B. 15-20%
Explanation
Following a complete hydatidiform mole, the risk of developing GTN is approximately 15-20%. This is significantly higher than the risk after a partial mole, which is approximately 1-5%. The higher risk with complete moles is due to the greater degree of trophoblastic proliferation. This is why close β-hCG surveillance is mandatory after evacuation of a complete mole. The 2-5% figure applies to partial moles, while 30-40% and 50-60% are overestimates.
Reference: Berek and Novak's Gynecology, 16th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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