A 35-year-old woman with complete hydatidiform mole undergoes suction evacuation. Histopathology confirms complete mole with marked trophoblastic hyperplasia and diffuse villous edema. What is the karyotype expected in this specimen?
- A 69,XXX triploid karyotype
- B 46,XX entirely of paternal origin (androgenesis) ✓
- C 46,XY with balanced biparental contribution
- D 45,XO Turner karyotype
Correct answer: B. 46,XX entirely of paternal origin (androgenesis)
Explanation
Complete hydatidiform mole classically results from fertilization of an empty ovum by a single sperm that duplicates, giving a 46,XX androgenetic karyotype. The 69,XXX triploid karyotype characterizes partial moles, where two sperm fertilize a normal ovum. Understanding this distinction is fundamental to the classification of gestational trophoblastic disease.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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