A 30-year-old woman with a history of in vitro fertilization presents at 7 weeks with acute abdominal pain. Serum β-hCG is 8,000 mIU/mL. Ultrasound confirms a viable intrauterine pregnancy and a separate right adnexal gestational sac with cardiac activity. What is the incidence of this condition in IVF pregnancies compared to spontaneous conceptions?
- A 1:1000 vs 1:4000
- B 1:100 vs 1:30,000 ✓
- C 1:10 vs 1:1000
- D 1:400 vs 1:10,000
Correct answer: B. 1:100 vs 1:30,000
Explanation
Heterotopic pregnancy is the coexistence of intrauterine and extrauterine pregnancies. It occurs in 1:30,000 spontaneous pregnancies but rises to 1:100 in IVF pregnancies due to multiple embryo transfers. The other options are incorrect epidemiological estimates.
Reference: Williams Obstetrics, 26th ed.
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Written and medically reviewed by the StethoPrep medical team.