A 30-year-old woman undergoes suction evacuation for suspected complete hydatidiform mole. Histopathology reveals a triploid karyotype (69,XXY) and the presence of fetal red blood cells within villous vessels. Which of the following best describes this finding?

• A Androgenetic diploid complete mole
• B Monogynic diandric triploid complete mole
• C Diandric monogynic triploid partial mole ✓
• D Monosomy X mosaic partial mole

Explanation

Partial hydatidiform mole is characteristically triploid (69 chromosomes), most commonly diandric monogynic (two paternal and one maternal chromosome set). The presence of fetal red blood cells within villous vessels is a hallmark of partial mole, as complete moles have avascular villi without fetal tissue. Complete moles are androgenetically diploid (46,XX or 46,XY) with no fetal tissue.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.