A hysterectomy performed for persistently elevated beta-hCG after a complete molar pregnancy shows molar chorionic villi penetrating deep into the myometrial wall. The diagnosis is:
- A Choriocarcinoma
- B Invasive mole ✓
- C Placental site trophoblastic tumour
- D Exaggerated placental site reaction
Correct answer: B. Invasive mole
Explanation
Invasive mole is defined by invasion of molar chorionic villi through the myometrium, sometimes with vascular spread, and follows roughly 15 to 20 percent of complete moles. Choriocarcinoma is composed of anastomosing sheets of cytotrophoblast and syncytiotrophoblast and is characterised by the absence of chorionic villi. Placental site trophoblastic tumour consists of a monomorphic population of intermediate trophoblast, and exaggerated placental site reaction is a benign non-invasive process.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.