Cytogenetic analysis of a complete hydatidiform mole most commonly demonstrates:

• A 45,X monosomy
• B 69,XXY with one maternal and two paternal haploid sets
• C 46,XY with a normal biparental complement
• D 46,XX with all chromosomal material of paternal origin ✓

Explanation

Around 80 to 90 percent of complete moles are 46,XX arising from fertilisation of an empty ovum lacking maternal chromosomes by a 23,X sperm that then duplicates its DNA, so every chromosome is paternally derived. The remainder are 46,XY from dispermy of an empty ovum. Triploidy such as 69,XXY defines a partial mole, which retains fetal tissue and maternal genetic material.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.