A woman treated for GTN with chemotherapy is counselled about future pregnancy. After how long following complete remission (normalisation of beta-hCG) is pregnancy generally considered safe according to FIGO guidelines?

• A 12 months after normalisation of beta-hCG ✓
• B 6 months after normalisation of beta-hCG
• C 24 months after the last dose of chemotherapy
• D Immediately after completing chemotherapy if beta-hCG is normal

Explanation

FIGO recommends waiting 12 months after beta-hCG normalisation before attempting pregnancy in women who received multi-agent chemotherapy for high-risk GTN, to ensure surveillance is not interrupted and relapse risk has passed. For low-risk GTN treated with single-agent methotrexate, some guidelines allow 6 months of contraception after remission, but the conservative FIGO standard for high-risk is 12 months. Conception during surveillance risks obscuring relapse detection.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.