Which feature of a complete hydatidiform mole on cytogenetics distinguishes it from a partial mole?
- A Complete mole is triploid; partial mole is diploid
- B Complete mole arises from biparental conception with maternal contribution
- C Complete mole is diploid with androgenetic origin; partial mole is triploid ✓
- D Partial mole has higher malignant potential than complete mole
Correct answer: C. Complete mole is diploid with androgenetic origin; partial mole is triploid
Explanation
A complete hydatidiform mole is typically 46,XX (or 46,XY) with entirely paternal (androgenetic) chromosomal origin — the ovum nucleus is absent or inactivated, and all chromosomes derive from sperm. A partial mole is triploid (69 chromosomes), arising from fertilisation of an egg by two sperm. Complete moles have higher malignant potential (~15–20% develop GTN) compared to partial moles (~1–5%).
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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