A woman undergoes suction evacuation for a complete hydatidiform mole. Post-evacuation β-hCG is monitored. Which of the following findings indicates gestational trophoblastic neoplasia (GTN) requiring treatment?

• A β-hCG remains detectable at 4 weeks post-evacuation
• B β-hCG plateau for 3 weeks and then doubling in 2 weeks
• C β-hCG remains above 100 mIU/mL at 8 weeks post-evacuation
• D β-hCG plateau for 3 consecutive weeks within 6 months of evacuation ✓

Explanation

According to FIGO criteria for diagnosing GTN after molar evacuation, treatment is indicated when: (1) β-hCG plateau (less than 10% change) over 3 consecutive weekly measurements across 3 weeks, OR (2) β-hCG rise ≥10% over 3 consecutive values across 2 weeks, OR (3) β-hCG still elevated at 6 months, OR (4) histological diagnosis of choriocarcinoma. A plateau for 3 consecutive weeks is the most common criterion met in clinical practice and requires treatment initiation regardless of actual level.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.