A woman develops atonic PPH after vaginal delivery. Oxytocin infusion and uterine massage have failed. Carboprost 250 mcg is given intramuscularly. What is the maximum total dose of carboprost that can be administered?
- A 4 mg (16 doses)
- B 3 mg (12 doses)
- C 2 mg (8 doses) ✓
- D 1 mg (4 doses)
Correct answer: C. 2 mg (8 doses)
Explanation
Carboprost (15-methyl PGF2alpha) is given as 250 mcg IM every 15 to 90 minutes, with a maximum of 8 doses totaling 2 mg. Exceeding this dose increases the risk of bronchospasm, hypertension, and gastrointestinal side effects.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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