In the WOMAN trial, which drug was shown to reduce mortality from postpartum hemorrhage when given within 3 hours of birth?

• A Misoprostol
• B Recombinant factor VIIa
• C Fresh frozen plasma
• D Tranexamic acid ✓

Explanation

The WOMAN Trial (World Maternal Antifibrinolytic Trial, 2017) demonstrated that tranexamic acid, when given within 3 hours of delivery, significantly reduced death due to bleeding in women with postpartum hemorrhage without increasing thromboembolic events. This established tranexamic acid as a key adjunct in PPH management. Misoprostol is a uterotonic but was not the intervention in the WOMAN trial.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.