The WOMAN trial (2017) demonstrated that tranexamic acid for primary postpartum hemorrhage reduces death from bleeding if given within which time window of PPH onset?

• A Within 30 minutes
• B Within 1 hour
• C Within 6 hours
• D Within 3 hours ✓

Explanation

The WOMAN trial (2017), a large international RCT, found that tranexamic acid (1 g IV) given within 3 hours of postpartum hemorrhage onset significantly reduced death from bleeding (from 1.9% to 1.5%). Benefit was greatest when given within 1 hour but remained significant up to 3 hours; beyond 3 hours there was no significant reduction in mortality from hemorrhage. This parallels the CRASH-2 trial findings in trauma.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.