The WOMAN trial evaluated tranexamic acid in PPH. Which was the primary finding regarding mortality benefit?
- A Tranexamic acid reduced death from bleeding when given within 3 hours of delivery ✓
- B Tranexamic acid significantly reduced all-cause maternal mortality
- C Tranexamic acid reduced thromboembolic events in PPH
- D Tranexamic acid reduced hysterectomy rates by 50%
Correct answer: A. Tranexamic acid reduced death from bleeding when given within 3 hours of delivery
Explanation
The WOMAN trial (Lancet, 2017) enrolled >20,000 women with PPH and showed that tranexamic acid reduced death from bleeding (RR 0.81) with the benefit restricted to women treated within 3 hours of delivery; treatment after 3 hours showed no benefit. All-cause mortality was not significantly reduced. Hysterectomy rates were not significantly different. These findings supported the recommendation to administer tranexamic acid within 3 hours of PPH onset.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.