In the WOMAN trial, which intervention was shown to reduce mortality from postpartum hemorrhage when given within 3 hours of delivery?

• A Tranexamic acid ✓
• B Recombinant factor VIIa
• C Fibrinogen concentrate
• D Fresh frozen plasma

Explanation

The WOMAN trial (2017) demonstrated that tranexamic acid, an antifibrinolytic agent, reduces death due to bleeding in PPH when given within 3 hours of delivery without increasing thromboembolic events. The benefit was time-sensitive; treatment beyond 3 hours showed no survival benefit. This trial changed WHO PPH management guidelines.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.