The WOMAN trial assessed tranexamic acid administration for PPH. Which of the following best describes the trial's main finding regarding mortality?
- A Tranexamic acid significantly reduced death from bleeding when given within 3 hours of delivery ✓
- B Tranexamic acid significantly reduced all-cause maternal mortality
- C Tranexamic acid increased thromboembolic events and was not recommended
- D Tranexamic acid reduced hysterectomy rates but had no effect on mortality
Correct answer: A. Tranexamic acid significantly reduced death from bleeding when given within 3 hours of delivery
Explanation
The WOMAN trial (2017, Lancet) showed that tranexamic acid (1 g IV) significantly reduced death due to bleeding (risk ratio 0.81, p=0.045) when administered within 3 hours of delivery, without increasing thromboembolic events. It did not significantly reduce all-cause maternal mortality. Hysterectomy rates were not significantly different.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.