The WOMAN trial demonstrated that tranexamic acid given within 3 hours of postpartum haemorrhage diagnosis significantly reduced which outcome?

• A The total blood transfusion requirement
• B Rate of hysterectomy
• C Need for surgical intervention
• D Death due to bleeding ✓

Explanation

The WOMAN trial (2017) randomised 20,060 women with postpartum haemorrhage to tranexamic acid vs placebo. When given within 3 hours of delivery, tranexamic acid significantly reduced death due to bleeding (RR 0.69) without increasing thrombotic events. There was no significant reduction in hysterectomy rate or overall surgical intervention. This established tranexamic acid as a priority intervention in PPH within the 3-hour treatment window.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.