The WOMAN trial demonstrated that administering tranexamic acid within how many hours of PPH onset provided significant reduction in death due to bleeding?
- A 1 hour
- B 2 hours
- C 3 hours ✓
- D 6 hours
Correct answer: C. 3 hours
Explanation
The WOMAN trial (Lancet 2017, 20,000+ women) showed that IV tranexamic acid 1 g given within 3 hours of delivery significantly reduced death due to bleeding (relative risk 0.81) without increasing thromboembolic events. Treatment after 3 hours showed no mortality benefit, highlighting the importance of early administration in the fibrinolytic cascade.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.