Which of the following uterotonic agents acts via prostaglandin F2α receptors on uterine smooth muscle and is specifically contraindicated in asthma?
- A Carboprost (15-methyl PGF2α) ✓
- B Oxytocin
- C Misoprostol
- D Ergometrine
Correct answer: A. Carboprost (15-methyl PGF2α)
Explanation
Carboprost (15-methyl PGF2α) is a synthetic analogue of prostaglandin F2α that acts on FP (prostaglandin F) receptors causing intense uterine contraction. PGF2α also causes bronchoconstriction via TP and FP receptors in bronchial smooth muscle, making carboprost absolutely contraindicated in asthma. Oxytocin acts via V1a-type oxytocin receptors; misoprostol acts on EP receptors and has bronchodilator properties; ergometrine acts via alpha-adrenergic and serotonin receptors.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.