A 28-year-old woman at 26 weeks gestation has a 75g OGTT: fasting glucose 88 mg/dL, 1-hour 192 mg/dL, 2-hour 154 mg/dL. Using IADPSG 2010 criteria, which of the following is the CORRECT interpretation?

• A Normal glucose tolerance — all values within normal limits
• B Gestational diabetes mellitus — 2-hour value ≥ 153 mg/dL satisfies IADPSG threshold ✓
• C Overt diabetes in pregnancy — 2-hour value alone is diagnostic
• D Impaired glucose tolerance — a second test is required at 32 weeks

Explanation

IADPSG 2010 (adopted by WHO 2013) criteria for GDM diagnosis on 75g OGTT: fasting ≥ 92 mg/dL, OR 1-hour ≥ 180 mg/dL, OR 2-hour ≥ 153 mg/dL — any ONE value meeting or exceeding the threshold is diagnostic. This patient's 2-hour glucose is 154 mg/dL (≥ 153), which meets the GDM threshold. Fasting 88 mg/dL is normal (< 92), and 1-hour 192 mg/dL exceeds the 1-hour threshold of 180 mg/dL — actually both the 1-hour and 2-hour values are abnormal here, further confirming GDM. Overt diabetes in pregnancy requires fasting ≥ 126 or 2-hour ≥ 200 or random ≥ 200 with symptoms.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.