The HAPO study (Hyperglycemia and Adverse Pregnancy Outcomes, 2008) redefined gestational diabetes diagnostic thresholds. IADPSG criteria (2010) derived from HAPO established which 75-g OGTT threshold for GDM diagnosis?

• A Fasting ≥126 mg/dL OR 1-hour ≥180 mg/dL OR 2-hour ≥153 mg/dL — any one value diagnostic
• B Two or more values must be met: fasting ≥95, 1-hour ≥180, 2-hour ≥155 mg/dL
• C Fasting ≥100 mg/dL and 2-hour ≥140 mg/dL on a 100-g OGTT
• D Fasting ≥92 mg/dL OR 1-hour ≥180 mg/dL OR 2-hour ≥153 mg/dL — any one value diagnostic ✓

Explanation

IADPSG criteria (based on HAPO study data — odds ratios for adverse outcomes at specific glucose thresholds) for 75-g OGTT: fasting plasma glucose ≥92 mg/dL, 1-hour ≥180 mg/dL, or 2-hour ≥153 mg/dL — diagnosis of GDM is made if ANY ONE threshold is met. These thresholds correspond to 1.75 times the odds of large-for-gestational-age, primary caesarean, cord C-peptide, and neonatal adiposity. This is distinct from the older Carpenter-Coustan criteria (100-g, 3-hour OGTT) requiring two values to be elevated. WHO 2013 adopted IADPSG criteria.

Reference: Williams Obstetrics, 26th ed.

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Written and medically reviewed by the StethoPrep medical team.