The HAPO (Hyperglycemia and Adverse Pregnancy Outcomes) study led to revised thresholds for gestational diabetes mellitus (GDM) diagnosis. The IADPSG criteria derived from HAPO define GDM as ANY ONE of the following on a 75g OGTT EXCEPT:
- A 2-hour plasma glucose ≥140 mg/dL (WHO 1999 cut-off) ✓
- B Fasting plasma glucose ≥92 mg/dL
- C 1-hour plasma glucose ≥180 mg/dL
- D 2-hour plasma glucose ≥153 mg/dL
Correct answer: A. 2-hour plasma glucose ≥140 mg/dL (WHO 1999 cut-off)
Explanation
The International Association of Diabetes in Pregnancy Study Groups (IADPSG) criteria, derived from the HAPO trial, diagnose GDM when ANY ONE of three values on a 75g OGTT meets or exceeds: fasting ≥92 mg/dL (5.1 mmol/L), 1-hour ≥180 mg/dL (10.0 mmol/L), or 2-hour ≥153 mg/dL (8.5 mmol/L). The WHO 1999 cut-off of 2-hour ≥140 mg/dL is the older threshold and is NOT part of the IADPSG/current DIPSI/WHO 2013 criteria.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.