Which of the following conditions in a woman requesting first-trimester medical abortion with mifepristone and misoprostol is a CONTRAINDICATION to this regimen?
- A Chronic adrenal insufficiency requiring replacement steroids ✓
- B Well-controlled asthma using salbutamol inhalers
- C Previous lower segment cesarean section
- D Body mass index of 35 kg/m2
Correct answer: A. Chronic adrenal insufficiency requiring replacement steroids
Explanation
Mifepristone blocks progesterone and also antagonizes glucocorticoid receptors, so chronic adrenal insufficiency, systemic corticosteroid dependence, and inherited porphyria are contraindications. Well-controlled asthma on beta-agonists is safe, unlike severe asthma dependent on oral steroids. Prior cesarean does not contraindicate first-trimester medical abortion, and obesity does not preclude the standard regimen.
Reference: WHO Abortion Care Guideline, 2022 ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.