A 28-year-old Rh-negative woman undergoes surgical evacuation for incomplete abortion at 10 weeks gestation. She has not previously received anti-D immunoglobulin. What is the appropriate dose and timing of anti-D immunoglobulin?
- A 50 mcg within 72 hours of evacuation
- B 300 mcg within 72 hours of evacuation ✓
- C 300 mcg at 28 weeks only
- D No anti-D is needed in first trimester
Correct answer: B. 300 mcg within 72 hours of evacuation
Explanation
For Rh-negative women undergoing abortion at or beyond 10 weeks gestation, 300 mcg of anti-D immunoglobulin should be administered within 72 hours of the procedure to prevent Rh isoimmunization. For first-trimester events before 10 weeks, 50 mcg may suffice, but at 10 weeks the standard is 300 mcg. Anti-D is indicated regardless of trimester to prevent sensitization, which could affect future pregnancies.
Reference: Williams Obstetrics, 26th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.